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Pathophysiology of Heart Failure

Total Credits: 1 including 1.0 AOA Category 1-A Credit(s)

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IOA - Indiana
Richard E Klabunde, PhD, PhD
58 Minutes
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Implications for Systolic and Diastolic Dysfunction

Learning Objectives

Describe the pressure and volume changes in a normal ventricle during the cardiac cycle.
Describe the relationship between stroke volume and pre-load.
Define heart failure caused by ventricular systolic and diastolic dysfunction.
List common causes of systolic and diastolic dysfunction and possible intracellular mechanisms.
Contrast intracardiac pressure and volume changes, and structural changes associated with systolic and diastolic dysfunction.
Describe the physiologic basis of different treatment modalities for improving ventricular function implications for Systolic and Diastolic Dysfunction.

Faculty Disclosure Declaration Statement

This presenter has no conflict of interest or disclosure to declare of any financial interest or other relationship with any commercial entities discussed in this educational presentation.

Accreditation Statement

This educational presentation was developed according to the planning, design, implementation and evaluation standards of the accreditation requirements for category 1 CME sponsors of the American Osteopathic Association (AOA).  The Indiana Osteopathic Association (IOA) is accredited by the AOA to provide osteopathic continuing medical education for physicians.

Grievance Policy Statement

If you have any questions or concerns about this educational experience, you may call the IOA office at (317) 926-3009 or send an email message to  All questions or concerns will be addressed promptly.



Richard E Klabunde, PhD, PhD's Profile

Richard E Klabunde, PhD, PhD Related seminars and products

Presently, Dr. Klabunde is a professor of physiology at Marian University College of Osteopathic Medicine (MUCOM) in Indianapolis, IN. He received his Ph.D. in physiology from the University of Arizona in Tucson, followed by postdoctoral training in pharmacology at the University of California in San Diego. Dr. Klabunde’s academic research focused on regulation of skeletal muscle and coronary circulation, and cardiac function. In 2012, he was awarded the Arthur C. Guyton Physiology Educator of the Year Award from the American Physiological Society. He has published more than 50 research articles and two textbooks on cardiovascular physiology and manages the content of two cardiovascular teaching websites.

Dr. Klabunde discloses that he has no relevant financial relationships with any organization producing, marketing, reselling, or distributing health care goods or services consumed by, or used on, patients relative to the content of this presentation.

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